Palindromic rheumatism in two non-identical brothers with identical HLA including DR4.

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Palindromic rheumatism in two non-identical brothers with identical HLA including DR4.

Two brothers, aged 52 and 44, who suffered from palindromic rheumatism (PR) for 12 and 15 years were studied. The disease remained palindromic in the older brother, while chronic deformities developed early in the course of the disease in the younger. Their identical HLA locus was A9,Aw19(29); B12,Bw22; Cw1; DR1, DR4.

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Dr. L. Grčevska, Department of Nephrology, Medical Faculty, Vodnjanska 17, YU-91000 Skopje (Yugoslavia) Dear Sir, Various heredofamilial diseases involve the kidney, but there are also renal diseases in which familial aggregation can occur, such as IgA glomerulopathy, lupus nephritis, membranous nephropathy and vesicoureteral reflux [1-4]. We want to present 3 brothers who developed signs of gl...

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Familial palindromic rheumatism: a possible association with HLA.

Palindromic rheumatism is very rare in children. The familial occurrence of the disease has been only briefly reported previously. A family is described here in which the mother and her 3 children suffered from typical palindromic rheumatism, which ran a benign course. All 4 members were seronegative and the HLA types of the children were identical. The HLA genotype of the mother was HLA A2, Cw...

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Osteochondritis dissecans is a disorder of unknown etiology that can result in fragmentation of osteochondral surfaces, most commonly of the knee, shoulder, elbow, and ankle. This may lead to sequelae of pain and an inability to participate in desired activities. Multiple theories exist as to the true cause of the disorder, but none have been fully proven. One such proposed etiology is genetic ...

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Comparing Non-Identical Objects

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ژورنال

عنوان ژورنال: Annals of the Rheumatic Diseases

سال: 1985

ISSN: 0003-4967

DOI: 10.1136/ard.44.3.202